Anti-PNPLA3 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution

Application

Anti-PNPLA3 antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

PNPLA3 mediates triacylglycerol hydrolysis in adipocytes and is involved in the balance of energy usage cum storage in adipocytes.

PNPLA3 (patatin like phospholipase domain containing 3) involves lipogenic transacetylase activity. Variation in PNPLA3 (patatin like phospholipase domain containing 3) is known to increase the fat content of hepatocytes, thereby promoting the severity of nonalcoholic liver disease. The gene is found to be associated with hepatic steatosis, liver fibrosis and cancer. PNPLA3 might be involved in energy homeostasis. PNPLA3 mediates triacylglycerol hydrolysis in adipocytes and is involved in the balance of energy usage cum storage in adipocytes.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Patatin like phospholipase domain containing 3 (PNPLA3) gene is mapped to human chromosome 22q13.3. The protein encoded by this gene is a triacylglycerol lipase.

Immunogen

PNPLA3 (AAH65195.1, 1 a.a. ~ 481 a.a) full-length human protein.SequenceMYDAERGWSLSFAGCGFLGFYHVGATRCLSEHAPHLLRDARMLFGASAGALHCVGVLSGIPLEQTLQVLSDLVRKARSRNIGIFHPSFNLSKFLRQGLGKCLPANVHQLISGKIGISLTRVSDGENVLVSDFRSKDEVVDALVCSCFMPFYSGLIPPSFRGVRYVDGGVSDNVPFIDAKTTITVSPFYGEYDICPKVKSTNFLHVDITKLSLRLCTGNLYLLSRAFVPPDLKVLGEICLRGYLDAFRFLEEKGICNRPQPGLKSSSEGMDPEVAMPSWANMSLDSSPESAALAVRLEGDELLDHLRLSILPWDESILDTLSPRLATALSEEMKDKGGYMSKICNLLPIRIMSYVMLPCTLPVESAIAIVQRLVTWLPDMPDDVLWLQWVTSQVFTRVLMCLLPASRSQMPVSSQQASPCTPEQDWPCWTPCSPEGCPAETKAEATPRSILRSSLNFFLGNKVPAGAEGLSTFPSFSLEKSL

Physical form

Solution in phosphate buffered saline, pH 7.4